Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma.
- Author:
Masafumi ARIMA
1
;
Takeshi FUKUDA
Author Information
- Publication Type:Review
- Keywords: Basophils; Asthma; Eosinophils; Mast cells; Prostaglandins; TH2 cells
- MeSH: Asthma/*etiology/immunology; Basophils/physiology; Eosinophils/physiology; Humans; Mast Cells/physiology; Prostaglandin D2/*physiology; Receptors, Immunologic/physiology; Receptors, Prostaglandin/physiology; Th2 Cells/*immunology
- From:The Korean Journal of Internal Medicine 2011;26(1):8-18
- CountryRepublic of Korea
- Language:English
- Abstract: Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. Recently, novel functions of PGD2 have been identified. To date, D prostanoid receptor (DP) and chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) have been shown to be major PGD2-related receptors. These two receptors have pivotal roles mediating allergic diseases by regulating the functions of various cell types, such as TH2 cells, eosinophils, basophils, mast cells, dendritic cells, and epithelial cells. This review will focus on the current understanding of the roles of PGD2 and its metabolites in TH2 inflammation and the pathogenesis of bronchial asthma.
