Correlation among fractional exhaled nitric oxide, child asthma control test, lung function and disease severity in children with asthmatic
10.3760/cma.j.issn.1673-4904.2019.08.004
- VernacularTitle:呼出气一氧化氮、儿童哮喘控制测试、肺功能与儿童支气管哮喘病情关系的研究
- Author:
Caihong SUN
1
;
Xiaomeng LIU
;
Yong JIANG
;
Jing LIU
;
Chong WANG
;
Zhaochuan YANG
;
Zhenghai QU
Author Information
1. 青岛大学附属医院儿科 266003
- Keywords:
Bronchial asthma;
Child;
Exhaled nitric oxide;
Lung function tests;
Asthma control test
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(8):682-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation among fractional exhaled nitric oxide (FeNO), child asthma control test(C-ACT) and lung function in asthmatic children and its clinical significance. Methods A total of 108 cases of asthmatic children in the Affiliated Hospital of Qingdao University from June 2016 to September 2018 were recruited. Forty-seven cases (47.44%) were in acute onset, 40 cases(40.37%) were in chronic persistent, and 21 cases (21.19%) were in paracmasis. FeNO, lung function and C-ACT score were measured, and the correlation among them was analyzed. Results The level of FeNO in acute onset patients and chronic persistent patients had no significant difference:(44.18 ± 25.47)×10-9 vs. (46.98 ± 27.50)×10-9, P>0.05, but the level of FeNO in paracmasis patients was lower [(24.43 ± 10.71) × 10-9], compared with that of acute onset patients and chronic persistent patients, there were significant differences (P < 0.01). The scores of C-ACT in three groups had significant difference (P < 0.01), and there were significant differences between any two groups (P <0.01). The levels of forced expiratory peak flow rate measured value as a percentage of predicted value (FEV1%) and forced expiratory volume and forced vital capacity ratio in the first second (FEV1/FVC) in acute onset patients were significantly lower than those in chronic persistent patients and paracmasis patients (P <0.01), and there were no significant differences between chronic persistent patients and paracmasis patients (P＞0.05). Conclusions Compared with lung functions and C-ACT, FeNO is a good biomarker to evaluate the airway inflammation of asthmatic children.
