Significance of soluble sera apoptosis inhibitive factor sFas in patients with Graves disease
10.3760/cma.j.issn.1673-4904.2019.08.002
- VernacularTitle:凋亡抑制因子可溶性Fas在Graves眼病研究中的意义
- Author:
Xuemei ZHOU
1
;
Jin WANG
;
Huiping YUAN
;
Yangyang YU
;
Lifeng WANG
Author Information
1. 哈尔滨医科大学附属第二医院眼科 150086
- Keywords:
Graves ophthalmopathy;
Apoptosis;
Soluble Fas
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(8):675-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the function of soluble apoptosis inhibitive factor Fas (sFas) in pathogenesis of Graves ophthalmopathy (GO). Methods The subjects were enrolled in the Second Affiliated Hospital of Harbin Medical University from January 2014 to January 2017, and they were divided into three groups: GO accompanied with Graves disease (GD) group, GO without GD group and normal control group, with 30 patients in each group. Serum levels of sFas in three groups were investigated with enzyme-linked immunosorbent assay, and serum levels of freeing triiodothyronine (FT3), serum free thyroxine (FT4), thyrotrophin (TSH), thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb) were measured by chemoluminescent technique, and compared. Results The serum level of sFas in GO accompanied with GD group was (0.76 ± 0.13)μg/L, which was higher than that in GO without GD group [(0.63 ± 0.08)μg/L] and normal control group [(0.52 ± 0.05)μg/L], and there was significant difference (P＜0.01). The serum level of sFas in GO without GD group and normal control group had significant difference (P＜0.05). The serum levels of FT3, FT4, TGAb, TPOAb in GO without GD group were lower than those in GO accompanied with GD group (P＜0.01).The serum level of TSH in GO without GD group was higher than that in GO accompanied with GD group (P＜0.01). The concentration of sFas were negatively correlated with FT3, FT4, TSH, TGAb and TPOAb (P > 0.05). Conclusions Abnormal serum concentration of sFas can be observed in patients with GD and GO which proves that sFas may play a role in the pathogenesis of GD and GO.
