Relationship between the initial change of thyroglobulin and outcome in differentiated thyroid carcinoma patients with pulmonary metastases after 131I treatment
10.3760/cma.j.issn.1673-4904.2019.07.006
- VernacularTitle:131I治疗分化型甲状腺癌肺转移患者甲状腺球蛋白早期变化幅度与疾病转归的关联分析
- Author:
Jun WU
1
;
Yanxia ZHANG
;
Caixia JIN
;
Shihao HUANGFU
;
Luxiao QIAO
Author Information
1. 山西医科大学汾阳医院 山西省汾阳医院核医学科 032200
- Keywords:
Thyroid neoplasms;
Thyroglobulin;
Iodine radioisotopes;
Lung metastasis
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(7):596-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the initial change of thyroglobulin (Tg) and clinical outcome in differentiated thyroid carcinoma (DTC) patients with pulmonary metastases after 131I treatment. Methods A total of 69 DTC patients with pulmonary metastases from January 2010 to December 2015 were retrospectively analyzed. Patients were divided into 3 groups according to the variation of Tg: groupⅠ(Tg declined≥ 50%), groupⅡ(Tg declined＜50% or Tg increased＜10%), and group Ⅲ (Tg increased ≥10% ). The follow-up time was (49.2 ± 9.3) months. Clinical outcomes were divided into remission, stable disease and progressive disease according to the serum test and imaging results. Results The percentage of group Ⅰ, Ⅱ, Ⅲ patients was 44.9% (31/69), 40.6% (28/69), and 14.5% (10/69) respectively. Results of follow-up showed 19.4% (6/31) patients achieved remission and 80.6% (25/31) had stable disease in groupⅠ. There were 10.7% (3/28) patients with remission, 60.7% (17/28) with stable disease and 28.6% (8/28) with progression disease in groupⅡ. All patients showed progressive disease in groupⅢ. The clinical outcome was related to the variation of Tg after 131I treatment (P＜0.01). Conclusions Initial Tg after 131I treatment could be a predictor to the outcome of patients. The increased Tg level indicates a high possibility of 131I refractory disease.
