Influence of intensive drug program on blood pressure, cardiac function and laboratory parameters of elderly patients with type H hypertension
10.3760/cma.j.issn.1673-4904.2019.06.012
- VernacularTitle:强化药物方案对老年H型高血压患者血压、心脏功能及实验室指标的影响
- Author:
Peng RONG
1
;
Mu SUN
;
Yanhu SHI
Author Information
1. 陕西省宝鸡中医医院心内科 721000
- Keywords:
Elderly;
Hypertension,type H;
Drug;
Comparative study
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(6):530-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of enalapril maleate and folic acid combined with Vitamin B6 (VB6)+Vitamin B12 (VB12) on blood pressure, cardiac function and laboratory parameters of elderly patients with type H hypertension. Methods One hundred and fifty-six elderly patients with type H hypertension were chosen in the period from January 2015 to March 2016 in Traditional Chinese Medicine Hospital of Baoji City and randomly divided into both groups including control group (78 patients,enalapril maleate and folic acid used alone) and observation group (78 patients,VB6+VB12 on the basis of control group); and the levels of blood pressure, cardiac function, homocysteic acid (Hcy), human soluble intercellular adhesion molecule-1(sICAM-1), nitric oxide (NO) and endothelin-1 (ET-1) before and after treatment and the incidence of major cardiovascular events of both groups were compared. Results The levels of 24 h systolic blood pressure mutation rate (24 h SBPV), 24 h diastolic blood pressure variability (24 h DBPV), day systolic blood pressure mutation rate (dSBPV), day diastolic blood pressure variability (dDBPV), night systolic blood pressure mutation rate (nSBPV) and night diastolic blood pressure variability (nDBPV) after treatment in observation group were significantly lower than those in control group and before treatment (P < 0.05). The levels of interventricular septum thickness (IVST), left ventricular end diastolic diameter (LVDd), left ventricular end systolic diameter (LVDs) and left ventricular ejection fraction (LVEF) after treatment of observation group were significantly better than those ofcontrol group and before treatment (P<0.05). The levels of Hcy, sICAM-1, NO and ET-1after treatment of observation group were significantly better than those of control group and before treatment (P < 0.05). Conclusions Intensive drug program in the treatment of elderly patients with type H hypertension can efficiently control blood pressure level, improve cardiac function, regulate the levels of Hcy, sICAM-1, NO and ET-1 and be helpful to prevent major cardiovascular events.
