The value of Ki-67 expression in the prognosis of triple negative breast cancer patients
10.3760/cma.j.issn.1673-4904.2019.05.003
- VernacularTitle:Ki-67表达在三阴性乳腺癌患者预后中价值分析
- Author:
Sijia LI
1
;
Manman LI
;
Hui LIU
;
Zhuo CHEN
;
Tian TIAN
Author Information
1. 郑州大学附属肿瘤医院乳腺外科 450000
- Keywords:
Ki-67 antigen;
Prognosis;
Triple negative breast cancer;
Clinical stage
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(5):392-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of Ki-67 expression in the prognosis of triple negative breast cancer (TNBC) patients. Methods The expression of Ki-67 in 100 cases of TNBC was detected by EnVision method. According to the median of Ki-67, the patients were divided into low expression group and high expression group. The value of Ki-67 expression in the prognosis of TNBC was analyzed. Results The median Ki-67 was 30% . There were 52 cases in the Ki-67 low expression (≤ 30% ) group, and 48 cases in Ki-67 high expression (> 30% ) group. The expression of Ki-67 was correlated with histological grade, tumor size and lymph node status (P<0.01). Histological gradeⅠtoⅡ and primary tumor T1 were independent influencing factors of high expression of Ki-67 (P < 0.01). Kaplan-Meier analysis showed that Ki-67 was statistically related to disease-free survival (DFS) and overall survival (OS) (P<0.05). Univariate COX analysis showed that tumor size, lymph node status, Ki-67 were statistically correlated with DFS and OS (P<0.05). Multivariate analysis showed that tumor size, lymph node status, and Ki-67 were independent prognostic factors of DFS and OS (P<0.05 or<0.01). Primary tumors with T1, non-metastatic lymph nodes, and higher expression of Ki-67 in TNBC patients had longer DFS and OS (P < 0.01 or < 0.05). Conclusions Low expression of Ki-67 (≤ 30% ) is associated with poor disease stage and prognosis in TNBC. 30% may be the best cut-off value of Ki-67.
