Influence of ultrasound‐guided lauromacrogol foam sclerotherapy on peripheral blood levels of CEC , ET‐1 and NO in patients with saphenous vein varicosis／
10.3969/j.issn.1008－0074.2019.04.24
- VernacularTitle:超声引导聚桂醇泡沫硬化剂治疗对大隐静脉曲张患者外周血 CEC 、 ET‐1 及 NO 值的影响
- Author:
Shao‐yin SHAN
1
;
Peng YUAN
;
Tian‐hua YUE
;
Shi WU
;
Jin‐dan WU
;
Xian‐chen HUANG
Author Information
1. 江苏省建湖县人民医院介入与血管外科
- Keywords:
Varicose veins;
Endothelium,vascular;
Therapy
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(4):486-490
- CountryChina
- Language:Chinese
-
Abstract:
To explore influence of ultrasound‐guided lauromacrogol foam sclerotherapy on peripheral blood levels of counting of endothelial cells (CEC) , endothelin (ET)‐1 and nitric oxide (NO) in patients with sa‐phenous vein varicosis .Methods : A total of 90 patients with saphenous vein varicosis were randomly and equally di‐vided into lauromacrogol group (received ultrasound‐guided lauromacrogol foam sclerotherapy ) and routine treat‐ment group (received routine stripping ).Peripheral blood levels of CEC , ET‐1 and NO were observed and com‐pared between two groups before and after surgery , and therapeutic effect and incidence of complications were eval‐uated.Results : Compared with routine treatment group , there were significant reductions in surgery time [ (81. 79 ± 16.88) min vs .(40.55 ± 10. 19) min] , hospitalization time [(3.94 ± 1.36) d vs.(2. 17 ± 1.31) d] and hospital‐ization fee [ (7640. 15 ± 1025.11) RMB vs.(3998.89 ± 910. 67 ) RMB ] in lauromacrogol group , P＝ 0.001 all. Compared with routine treatment group after surgery , there were significant reductions in incidence rate of total complications (17.78% vs .4. 44%) , percentage of patient＇s condition class IV (17. 78% vs.4.44%) , peripheral blood levels of CEC [ (5562. 48 ± 1194. 73)／L vs.(4655.87 ± 1209. 88)／L] and ET‐1 [ (70. 32 ± 10.30) ng／L vs. (62.95 ± 13.78) ng／L] , and significant rise in percentage of patient’ s condition class I (6.67% vs.25. 00%) and peripheral blood NO level [(1.27 ± 0.42) μmol／L vs.(1. 59 ± 0.51) μmol／L] in lauromacrogol group , P＜0. 05 or＜0. 01. Conclusion : Ultrasound‐ guided lauromacrogol foam sclerotherapy can significantly increase therapeutic effect , improve vascular endothelial function in patients with saphenous vein varicosis .And its complications are few .
