Therapeutic effect of early use of nicorandil on patients with myocardial infarction undergoing PCI and its influence on cardiac function／
10.3969/j.issn.1008－0074.2019.04.20
- VernacularTitle:早期使用尼可地尔对心肌梗死患者 PCI 临床疗效以及心功能的影响
- Author:
Jing YANG
1
;
Ri‐yang GAO
;
Yun LI
;
Duo‐hong WU
Author Information
1. 海口市第四人民医院心血管内科
- Keywords:
Myocardial infarction;
Angioplasty,balloon,coronary;
Percutaneous;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(4):469-472
- CountryChina
- Language:Chinese
-
Abstract:
To observe therapeutic effect of early use of nicorandil on patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) and its influence on cardiac function .Methods : A total of 124 MI patients undergoing PCI in our hospital from 2016 to 2018 were randomly and equally divided into PCI group and nicorandil + PCI group (received nicorandil based on PCI group ) , both groups were treated for 28d. Therapeutic effect , incidence of adverse , LVEF , LVEDd and cardiac index (CI) before and three months after PCI were recorded and compared between two groups .Results : Compared with PCI group , there was significant rise in total effective rate (72.6% vs .90.3%) , and significant reductions in incidence rates of recurrent angina pectoris (25.8% vs.11.3%) and malignant arrhythmia (22.6% vs.8.1%) in nicorandil + PCI group , P＜0. 05 all.Compared with before PCI , there were significant rise in LVEF and CI , and significant reduction in LVEDd in two groups on three months after PCI ;compared with PCI group , there were significant rise in LVEF [ (40.52 ± 4.38)% vs.(46.81 ± 4.53)%] and CI [ (2.43 ± 0.35) L·min－1 ·m－2 vs.(2.66 ± 0.38) L·min－1 ·m－2 ] , and significant reduction in LVEDd [ (54. 32 ± 6.23) mm vs.(48. 24 ± 5.34) mm] in nicorandil + PCI group on three months after PCI , P＝0.001 all.There was no significant difference in incidence rate of adverse drug reactions dur‐ing treatment between two groups , P＝0.753. Conclusion : Early use of nicorandil can significantly improve thera‐peutic effect , contribute to recovery of cardiac function with good safety in MI patients undergoing PCI , which is worth extending .
