Therapeutic effect of valsartan combined beraprost sodium on hypertension complicated early renal in‐jury／
10.3969/j.issn.1008－0074.2019.04.11
- VernacularTitle:缬沙坦联合贝前列素钠治疗高血压合并早期肾损害的疗效
- Author:
Ke‐qing FENG
1
;
Jin‐liang ZHANG
;
Zi‐jian ZHOU
;
Wen‐juan WANG
Author Information
1. 梅河口市中心医院心内科
- Keywords:
Hypertension,renal;
Valsartan;
Beraprost sodium
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(4):434-437
- CountryChina
- Language:Chinese
-
Abstract:
To observe and analyze therapeutic effect of valsartan combined beraprost sodium on patients with hypertension (EH) complicated early renal injury (ERI).Methods : A total of 480 EH + ERI patients treated in our hospital in near two years were randomly and equally divided into valsartan group and combined treatment group (received valsartan combined beraprost sodium) , both groups were treated for three months .Levels of blood pressure , renal function related indexes were compared between two groups before and after treatment .Results :Compared with before treatment , after three months , there were significant reductions in levels of blood pressure , serum creatinine , urine β2 microglobulin and D‐dimer , and significant rise in creatinine clearance rate (Ccr) in two groups , P＝0.001 all.Compared with valsartan group after treatment , there were significant reductions in levels of blood pressure [ (130. 92 ± 5.92)／(80.18 ± 6.69) mmHg vs.(120. 93 ± 6. 53)／(69.98 ± 6.32) mmHg] , serum creatinine [ (93.92 ± 10. 49) μmol／L vs.(83. 14 ± 11. 03) μmol／L] , urine β2 microglobulin [ (385.41 ± 35.54) μg／L vs.(362.65 ± 26.59) μg／L] and D‐dimer [ (1. 75 ± 0.44) mg／L vs.(1. 01 ± 0.11) mg／L] , and significant rise in Ccr [ (63.22 ± 7. 66) ml／min vs.(79.13 ± 8.83) ml／min] in combined treatment group , P＝0.001 all.Conclusion :Compared with valsartan monotherapy , valsartan combined beraprost sodium can more significantly reduce blood pressure and protect renal function in hypertensive patients with early renal injury .
