Influence of Ginkgo ketone ester dropping pills combined atorvastatin on vascular endothelial function , serum omentin-1 and Hcy levels in EH patients with carotid arteriosclerosis
10.3969／j.issn.1008－0074.2019.03.26
- VernacularTitle:银杏酮酯滴丸联合阿托伐他汀对高血压伴颈动脉硬化患者血管内皮功能、血清网膜素-1 和 H cy 的影响
- Author:
Rui LIAO
1
;
Wei NI
;
De-Zhi LIN
Author Information
1. 内江市第一人民医院心内科
- Keywords:
Hypertension;
Carotid artery diseases;
Atorvastatin;
Ginkgo biloba
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(3):364-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To observe influence of Ginkgo ketone ester dropping pills (GKE) combined atorvastatin on vascular endothelial function ,serum levels of omentin-1 and homocysteine (Hcy) in hypertensive patients with ca-rotid arteriosclerosis (CAS).Methods : A total of 120 hypertensive patients with CAS treated in our hospital were selected ,randomly and equally divided into atorvastatin group and combined treatment group (received GKE com-bined atorvastatin ) ,both groups received corresponding therapy based on health education ,diet and exercise etc for 12 weeks.Blood pressure ,blood lipids ,carotid intima-media thickness (IMT ) ,plaque size ,levels of endothelin (ET)-1 ,nitric oxide (NO) ,serum omentin-1 and Hcy were compared between two groups before and after treat- ment .Results : Compared with before treatment ,there were significant reductions in blood pressure ,blood lipids (except significant rise in HDL-C) ,serum levels of ET-1 and Hcy ,IMT and plaque size ,and significant rise in ser-um levels of NO and omentin-1 in two groups after treatment , P＜0-01 all.Compared with atorvastatin group after treatment ,there were significant reductions in blood pressure ,blood lipids (except significant rise in HDL-C) ,ser-um levels of ET-1 [ (136-42 ± 15-57) μg／ml vs.(116-57 ± 13-28) μg／ml] and Hcy [ (15-46 ± 3-25 ) μmol／L vs. (10-58 ± 3-11) μmol／L] ,IMT [ (1-43 ± 0-21) mm vs.(1-26 ± 0-19) mm] and plaque size [ (22-53 ± 1-28) mm2 vs.(20-67 ± 1-14 ) mm2 ] ,and significant rise in serum levels of NO [ (102-43 ± 12-37) μmol／L vs.(129-84 ± 13-36) μmol／L] and omentin-1 [ (176-57 ± 45-20 ) μg／ml vs.(198-73 ± 45-38) μg／ml] in combined treatment group , P＜0-05 or ＜0-01- Conclusion : Ginkgo ketone ester dropping pills combined atorvastatin can significantly improve vascular endothelial function and arteriosclerosis while reducing blood pressure and blood lipids in hyperten-sive patients with carotid arteriosclerosis .
