Therapeutic effect of trimetazidine hydrochloride on aged patients with acute cardiomyopathy in acute phase and its influence on serum cytokine levels and cardiac function
10.3969／j.issn.1008－0074.2019.03.24
- VernacularTitle:盐酸曲美他嗪对老年急性心肌病患者的疗效及对血清细胞因子、心功能的影响
- Author:
Yan-Hong WANG
1
;
Dong-Xia HAO
Author Information
1. 航天中心医院老年一科
- Keywords:
Cardiomyopathies;
Trimetazidine;
Treatment outcome
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(3):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore therapeutic effect of trimetazidine hydrochloride on aged patients with acute ische-mic cardiomyopathy in acute phase and its influence on serum cytokine levels and cardiac function .Methods : A total of 90 aged patients with acute cardiomyopathy ,who were treated in our hospital from Dec 2014 to Dec 2016 ,were selected .Patients were randomly and equally divided into routine treatment group and trimetazidine group (received trimetazidine based on routine treatment ) ,both groups were treated for 12 weeks .Left ventricular ejection fraction (LVEF) ,left ventricular end-systolic dimension (LVESd) ,left ventricular end-diastolic dimension (LVEDd) ,ser-um levels of tumor necrosis factor (TNF)-α and interleukin (IL )-6 before and after treatment ,and therapeutic effect were measured and compared between two groups .Results : Total effective rate of trimetazidine group was significantly higher than that of routine treatment group (97-78% vs .77-77%) , P＝0-004- Compared with before treatment ,there were significant reductions in serum levels of TNF-α and IL-6 in two groups ;significant rise in LVEF ,and significant reductions in LVEDd and LVESd in trimetazidine group after treatment , P＜ 0-05 or ＜0-01- Compared with routine treatment group after treatment , there was significant rise in LVEF [ (60-89 ± 5-22)% vs.(65-01 ± 6-01 )%] , and significant reductions in LVESd [ (34-02 ± 5-00 ) mm vs .(30-27 ± 4-80 ) mm] ,LVEDd [ (51-22 ± 7-02) mm vs.(46-21 ± 5-44) mm] ,serum levels of TNF-α [ (282-97 ± 59-44) pg／ml vs. (248-89 ± 45-33) pg／ml] and IL-6 [ (721-02 ± 165-00 ) pg／ml vs.(630-89 ± 102-80 ) pg／ml] in trimetazidine group ,P＜0-01 all.Conclusion : Trimetazidine hydrochloride possesses certain anti-inflammation effect ,can signifi-cantly improve cardiac function and therapeutic effect in aged patients with acute cardiomyopathy ,which is worth extending .
