Comparison of therapeutic effects between dual-and triple-anticoagulant therapy after PCI in AF pa-tients with CHD
10.3969／j.issn.1008－0074.2019.03.15
- VernacularTitle:房颤合并冠心病患者冠脉支架植入术后二联和三联抗凝治疗的对比研究
- Author:
Hong ZHUANG
1
;
Su-Chuan ZHANG
;
Jun YIN
;
Wei JIANG
;
Feng YAO
;
Bo LIU
;
Lu HUANG
;
Ping YANG
;
Tian DAI
;
Yong ZOU
Author Information
1. 江汉大学附属医院心血管内科
- Keywords:
Atrial fibrillation;
Coronary disease;
Stents;
Anticoagulants
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(3):323-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore influence of dual-and triple-anticoagulant therapy on hemorrhage events ,laboratory in-dexes and cardiovascular events after percutaneous coronary intervention (PCI) in patients with atrial fibrillation (AF) complicated coronary heart disease (CHD).Methods : Clinical data of 100 AF + CHD patients were analyzed .All subjects received PCI and anticoagulant therapy after PCI .Dual-therapy group (n＝ 50) received dual-anticoagulant program and triple-therapy group (n＝50) received triple-anticoagulant program.Levels of blood C reactive protein (CRP) ,fibrinogen (Fg) ,D-dimer (D-D) and platelet count (PLT) before and after treatment ,incidence of hemorrhage events and adverse cardiovascular events during treatment were compared between two groups .Results : Compared with dual-therapy group af-ter 12-month treatment ,there were significant reductions in blood levels of CRP [(16-81 ± 4-49) mg／L vs.(7-86 ± 1-64) mg／L] ,PLT [ (298-47 ± 54-33)×109／L vs.(148-89 ± 23-11)×109／L] ,Fg [ (5-59 ± 1-41) g／L vs.(2-14 ± 0-56) g／L] and D-D [(0-37 ± 0-08) mg／L vs.(0-21 ± 0-06) mg／L] in triple-therapy group ,P＝0-001 all.Incidence rate of ad-verse cardiovascular events in triple-therapy group was significantly lower than that of dual-therapy group (6-00% vs. 22-00%, P＝0-021) ,there was no significant in incidence rate of hemorrhage events between two groups , P＝0-182-Conclusion : Triple-anticoagulant therapy can significantly improve therapeutic effect with high safety in AF + CHD pa-tients after PCI ,which is worth extending .
