Therapeutic effect of atorvastatin on CHD + DM patients and its influence on blood lipids ,hemorheol— ogy and coagulation
10.3969/j.issn.1008－0074.2019.02.22
- VernacularTitle:阿托伐他汀对冠心病合并糖尿病患者的疗效及对血脂、血流变与凝血功能的影响
- Author:
Jinrong WEN
1
;
Sheng FAN
Author Information
1. 云南省红河州第一人民医院心内科
- Keywords:
Coronary disease;
Type 2,diabetes;
Atorvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(2):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To observe therapeutic effect of atorvastatin on patients with coronary heart disease (CHD ) complicated diabetes mellitus and its influence on blood lipids ,hemorheological indexes and coagulation function . Methods : A total of 112 patients with type 2 diabetes mellitus (T2DM) complicated CHD ,who were treated in our hospital from Feb 2016 to Oct 2017 ,were enrolled .Patients were randomly and equally divided into routine treat—ment group and combined treatment group (atorvastatin+ routine treatment group ) ,both groups were treated for three months.Levels of blood glucose ,blood lipids ,coagulation function indexes :activated partial thromboplastin time (APTT) ,prothrombin time (PT) ,tissue plasminogen activator (t—PA) ,hemorheological indexes :whole blood viscosity ,plasma viscosity ,fibrin level and therapeutic effect were observed and compared between two groups be—fore and after treatment .Results : Total effective rate of combined treatment group was significantly higher than that of routine treatment group (98.21% vs.80.36%) , P＝0.002. Compared with before treatment ,after three—month treatment ,there were significant reductions in levels of FPG ,2hPG ,HbA1c ,TG ,TC ,LDL—C ,whole blood viscosity ,plasma viscosity ,fibrin ,and significant rise in levels of HDL—C ,APTT ,PT and t—PA in two groups except HDL—C and fibrin levels of routine treatment group , P＜0.05 or ＜0.01. Compared with routine treatment after three—month treatment ,there were significant reductions in levels of above blood glucose indexes ,TC ,TG ,LDL—C ,whole blood viscosity [ (12.19 ± 2. 67) mPa／s vs.(10.15 ± 2.18) mPa／s] ,plasma viscosity [ (2.31 ± 0.29 ) mPa／s vs .(1. 78 ± 0. 23) mPa／s] and fibrin [(3.29 ± 1.29) g／L vs.(2. 29 ± 0.94) g／L] ,and significant rise in lev—els of HDL—C ,APTT [ (29.98 ± 2.92) s vs.(32.07 ± 3.24) s] ,PT [ (13. 89 ± 1.63) s vs.(15. 14 ± 1.75) s] and t—PA [ (394. 62 ± 12. 76) U／L vs .(437. 56 ± 13. 54) U／L] in combined treatment group , P＜0. 05 or ＜0.01. Con—clusion : Atorvastatin can significantly reduce blood lipid levels ,contribute to improving hemorheological indexes and coagulation function in CHD + DM patients .
