Therapeutic effect of allisartan isoproxil tablet on carotid atherosclerosis lesion in patients with essen‐tial hypertension／
10.3969/j.issn.1008-0074.2019.01.12
- VernacularTitle:阿利沙坦酯片治疗原发性高血压患者颈动脉硬化病变的疗效
- Author:
Ting XI
1
;
Xueguang JI
;
Jing ZHOU
;
Wenjing QU
;
Hong GONG
;
Xiangting DONG
;
Li MA
;
Ting LIU
;
Qiaoli WANG
Author Information
1. 延安大学附属医院心脑血管专科病区冠心病一病区
- Keywords:
Hypertension;
Carotid artery Dis;
Allisartan isoproxil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(1):46-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To evaluate therapeutic effect of allisartan isoproxil tablet on carotid atherosclerosis (CAS) le‐sion in patients with mild to moderate essential hypertension (EH).Methods :A total of 120 patients with mild to moderate EH complicated CAS treated in our hospital were enrolled .They were randomly divided into valsartan group (n＝60 ,received valsartan 80mg／d) and allisartan isoproxil group (n＝60 ,received allisartan isoproxil tablet 240mg／d) ,both groups received measure by carotid vascular ultrasound before treatment ,24 weeks and 48 weeks af‐ter treatment and its result were compared between two groups .Results :Compared with before treatment ,there were significant reductions in IMT ,size ,thickness and number of carotid atherosclerotic plaques on 24 weeks and 48 weeks after treatment in two groups ,and above indexes of 48 weeks were significantly lower than those of 24 weeks , P＜0.05 or ＜0.01. The decreased value of IMT in allisartan isoproxil group was significantly higher than that of valsartan group ,and there were no significant difference between two groups in time point of size ,thickness and number of carotid atherosclerotic plaques , P＞0.05 all.Conclusion :Therapeutic effect of two drugs on size ,thick‐ness and number of carotid atherosclerotic plaques are similar ;but therapeutic effect of allisartan isoproxil tablet on IMT is significantly better than that of valsartan .
