Congenital diaphragmatic hernia: perioperative management of 4 cases on extracorporeal membrane oxygenation
10.3760/cma.j.issn.2096-2932.2019.05.009
- VernacularTitle:体外膜肺氧合下先天性膈疝的围术期管理
- Author:
Qiuming HE
1
;
Wei ZHONG
;
Zhe WANG
;
Junjian LYU
;
Li MA
;
Guodong HUANG
;
Tulian LIN
;
Jiakang YU
Author Information
1. 广州市妇女儿童医疗中心新生儿外科 510623
- Keywords:
Hernia;
diaphragmatic;
Extracorporeal membrane oxygenation;
Perioperative management;
Surgical technology
- From:Chinese Journal of Neonatology
2019;34(5):363-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the experience of perioperative management for repair of congenital diaphragmatic hernia (CDH) supported by extracorporeal membrane oxygenation (ECMO). Method Retrospective review was conducted for the clinical data of CDH patients who received surgical repair on ECMO from December 2016 to June 2018 in Guangzhou Women and Children's Medical Center. Result Four fetus with prenatal diagnosis of left-side CDH were transferred to our Center and received standardized perinatal management. Moderate-severe pulmonary hypoplasia was recognized after evaluation by fetal imaging. Four cases were initiated with veno-arterial ECMO at 3, 35, 41, 11 h of life, respectively. Repair of the diaphragmatic defect was performed within two weeks after cannulation of ECMO. Furthermore, activated clotting time goals were adjusted to 180～220 s, activated partial thromboplastin time were stabilized between 50～80 s, platelets count were maintained>100×109/L and hematocrit was kept>30％before the surgery. The surgeries of four patients were completed on the 0.9th, 0.5th, 3.6th, 5.1th day of life on ECMO, respectively. The defect was repaired by parachute patch. The operative time was 85～210 min. According to CDH Staging System defect size (A to D), there were two with defects at grade C and other two at grade D. Postoperative total volume of drainage was 215～1301 ml and ECMO duration was 3.0～39.3 d. Three of them survived during neonatal period, while one died. Conclusion Repair of CDH on ECMO is feasible and help to improve neonatal survival, especially for those with moderate-severe pulmonary hypoplasia.
