Cord blood vitamin D levels and its relationship to early-onset sepsis in the very low birth weight infants
10.3760/cma.j.issn.1673-4912.2019.08.011
- VernacularTitle:极低出生体重儿脐血维生素D水平与早发型败血症的相关性研究
- Author:
Yongyan SHI
1
;
Xuewei CUI
;
Ziyun LIU
;
Jun LI
;
Xindong XUE
;
Jianhua FU
Author Information
1. 中国医科大学附属盛京医院新生儿科
- Keywords:
Preterm;
Very low birth weight infants;
Early-onset sepsis;
25-hydroxy-vitamin D
- From:
Chinese Pediatric Emergency Medicine
2019;26(8):604-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between serum 25(OH) D levels and the inci-dence of early-onset sepsis(EOS) in the very low birth weight infants(VLBWI) and the gestational age be-low 34 weeks. Methods The cord blood of 159 VLBWI were collected between January and December 2017,including 31 clinically diagnosed EOS and 128 non-EOS patients. Serum 25(OH)D<10 ng/ml was de-fined as severe vitamin D deficiency,25(OH)D 10 to 20 ng/ml as vitamin D deficiency,25(OH)D 20 to 30 ng/ml as vitamin D insufficiency and 25(OH)D >30 ng/ml as vitamin D sufficiency. Results There were no differences in gender,gestational age,birth weight and Apgar score between the EOS group and the non-EOS group(P>0. 05). Serum 25(OH) D was(9. 08 ± 4. 21) ng/ml in the EOS group and(11. 91 ± 5. 37) ng/ml in the non-EOS group(P＝0. 007). The rate of severe vitamin D deficiency was 67. 7%(21/31)in the EOS group and 41. 4%(53/128) in the non-EOS group. The rate of vitamin D deficiency was 32. 3%(10/31)in the EOS group and 52. 3%(67/128)in the non-EOS group. But there was no difference of vitamin D deficiency distribution in the two groups(P＝0. 152). The cut-off value of serum 25(OH)D level in predic-ting EOS was 10. 06 ng/ml. Conclusion The incidence of vitamin D deficiency is as high as 95%,calling for urgent attention on vitamin D supplementation in those VLBWI. Low 25(OH)D level( <10 ng/ml)might be predictive of EOS.
