Mitochondrial function injury mechanism in septic cardiomyopathy
10. 3760/cma. j. issn. 1673‐4912. 2019. 05. 011
- VernacularTitle:线粒体功能损伤在脓毒症心功能障碍中的研究进展
- Author:
Tao ZHANG
1
;
Chunfeng LIU
Author Information
1. 中国医科大学附属盛京医院PICU
- Keywords:
Septic cardiomyopathy;
Mitochondrial;
Oxidative stress;
Mitochondrial uncoup‐ling;
Mitochondrial homeostasis
- From:
Chinese Pediatric Emergency Medicine
2019;26(5):372-377
- CountryChina
- Language:Chinese
-
Abstract:
Septic cardiomyopathy is a common complication in severe sepsis and septic shock,mito‐chondrial function injury is one of the main aspects of its pathogenesis. The heart is a continuous power or‐gan,needs a lot of ATP to maintain normal systolic and diastolic function. Mitochondrial as the main ATP producing organelles,accounts for about one third of the myocardial volume,which being damaged will be harmful to the myocardial energy supply and cardiac function. This paper introduced the latest research pro‐gress of mitochondrial damage in septic cardiomyopathy,including mitochondrial NO production increase and oxidative stress,Ca2+ overload and mitochondrial membrane permeability increase,mitochondrial uncoupling and mitochondrial homeostasis,also discussed the potential treatments.
