Prediction of B cell Epitopes and HLA I Restricted CTL Epitopes Derived from Tumor Antigen SCCAg
10.3969/j.issn.1671-332X.2019.02.024
- VernacularTitle:肿瘤抗原SCCAg B细胞抗原表位及HLA Ⅰ类限制性CTL表位的生物信息学分析
- Author:
Xue HANG
1
;
La HU
;
Zicheng ZENG
;
Hai LIN
;
Gao YI
;
Zhaoyu LIU
Author Information
1. 广州医科大学附属第五医院 广州510700
- Keywords:
SCCAg;
B Cell Epitopes;
CTL Epitopes
- From:Modern Hospital
2019;19(2):240-244
- CountryChina
- Language:Chinese
-
Abstract:
Ojbective To predicte the HLAⅠrestricted CTL epitopes and B cell antigen epitopes derived from tumor antigen SCCAg. Methods The linear B cell epitopes and conformational B cell epitopes of tumor antigen SCCAg were predicted by Ellipro program. In addition, the HLAⅠrestricted CTL epitopes of SCCAg were predicted by NetCTL, Prot-Param and so on. Results B cell epitopes analysis revealed that SCCAg had 10 potential linear B cell epitopes and 5 conformational B cell epitopes; Combined with peptide HLAⅠbinding, proteasomal C - terminal cleavage and TAP transport efficiency, the NetCTL predicts that multiple HLAⅠrestricted CTL epitopes were present in the tumor antigen SCCAg. Conclusion The B cell epitopes and HLAⅠrestricted CTL epitopes can be predicted by multiple methods, which may lay the foundation for the further research on immunotherapy for targeting SCCAg.
