Progress of correlation between bone marrow dose-volume parameters and acute hematologic toxicity in pelvic malignant tumor

VernacularTitle:盆腔肿瘤IMRT下骨髓剂量-体积参数与急性血液学毒性相关性研究进展
Author: Hongbo CHEN ^{1
,

2} ; Zengrong YU ; Xiaofan DING ; Lin XIAO
Author Information

1. 中山大学附属江门医院/江门市中心医院肿瘤科二区(江门 529000)
2. 中山大学附属江门医院/江门市中心医院放射治疗中心
Keywords: Pelvic malignant tumors; Radiotherapy; Myelosuppression; Functional bone marrow; Dose-volume
From: Practical Oncology Journal 2019;33(4):361-366
CountryChina
Language:Chinese
Abstract: There is a high risk of myelosuppression in pelvic malignant tumors during concurrent chemoradiotherapy. The dose-volume relationship of pelvic exposed bone marrow( bone) is related to acute hematological toxicity during radiotherapy and chemotherapy,but lacks recognized parameters in this respect. The hematopoietic capacity of the bone marrow(bone)in different parts of the pelvic cavity is heterogeneous,and the pelvic bone marrow near the central axis has the strongest hematopoietic capacity,namely functional bone marrow. The relationship between dose-volume parameters of pelvic functional bone marrow and acute hematologic toxicity during chemoradiotherapy of pelvic malignant tumors may be the future direction.