Advances progress of N6-methyladenine and cancer
10. 11904/j. issn. 1002-3070. 2019. 04. 013
- VernacularTitle:N6-甲基腺嘌呤与癌症的研究进展
- Author:
Meiyin ZHANG
1
;
Ge LOU
Author Information
1. 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081
- Keywords:
N6-methyladenine(m6 A);
Methyltransferases;
Demethylases;
Cancer;
Epigenetics
- From:
Practical Oncology Journal
2019;33(4):357-360
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenine(m6 A),a major RNA methylation modification,affects the development and progression of hu-man cancer through a variety of mechanisms. The m6 A modification also affects multiple aspects of RNA metabolism,ranging from RNA processing,nuclear export,RNA translation to decay. In this review,the basic concepts of m6 A methylation,regulation of m6 A methyltransferase complex and m6 A demethylases in several cancers and some m6 A performed the biological function of the modifica-tion as m6 A-binding proteins are introduced. In addition,the dual role of m6 A methylation and its potential in clinical application are summarized in this review.
