Progress in long-chain non-coding RNA in osteosarcoma
10.11904/j.issn.1002-3070.2019.03.014
- VernacularTitle:长链非编码RNA在骨肉瘤中的研究进展
- Author:
Yishu LIU
1
;
Guofan QU
Author Information
1. 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081
- Keywords:
Osteosarcoma;
Long-chain non-coding RNA;
Tumor
- From:
Practical Oncology Journal
2019;33(3):266-270
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma(OS)is a malignant tumor that occurs mostly in children and adolescents with a poor prognosis. The 5-year survival rate and the survival rate of patients with lung metastasis or distant metastasis are still unsatisfactory. Currently,the treatment of osteosarcoma is still unsatisfactory under the bottleneck period. Long-chain non-coding RNA(LncRNA)is a non-pro-tein-encoding RNA molecule involved in a variety of processes including gene expression,chromatin remodeling,post-transcription-al processing and transcription. LncRNAs are abnormally expressed in human cancers and they are involved in tumor development, progression and metastasis. This article reviews the research progress of long-chain non-coding RNA in osteosarcoma,which is in-tended to provide further research for osteosarcoma and propose new diagnosis and treatment strategies.
