Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats
10.11904/j.issn.1002-3070.2019.03.004
- VernacularTitle:伏核微量注射异丁司特对吗啡成瘾大鼠甩尾痛阈的影响
- Author:
Qiuju XU
1
;
Guangwen ZHANG
Author Information
1. 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)
- Keywords:
Nucleus accumbens;
Ibudilast;
Morphine-addicted;
Tail-flick latency
- From:
Practical Oncology Journal
2019;33(3):211-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the effect of microinjection ibudilast on the appendix pain threshold in nucleus accumbens(NAC)of morphine-addicted rats. Methods Normal rats and morphine-addicted rats were injec-ted with ibudilast(5 μg/2 μL)or saline(2 μL)into NAC through glass microelectrode. The tail-flick period(TFL)was used as an in-dicator to observe the thermal pain threshold before and after ibuilast injection. Results After injected ibudilast 5 μg into the NAC of normal rats and morphine-added rats,the TFL was prolonged compared with that before injection,and the TFL prolongation of mor-phine-addicted rats was more significant than that of normal rats. There was no significant change in TFL after 2 μL of saline was in-jected into the NAC of normal rats and morphine-addicted rats. Conclusion Microinjection of ibudilast into NAC of normal rats and morphine-added rats can cause analgesic effect,and the analgesic effect of morphine-addicted rats is more significant.
