Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis
10.11904/j.issn.1002-3070.2019.03.003
- VernacularTitle:CXCR家族蛋白在不同乳腺癌亚型中的表达及临床预后分析
- Author:
Xiaoya WANG
1
;
Bin XIAO
;
Yang LIAO
;
Rongzhi TANG
;
Zhaohui SUN
;
Linhai LI
Author Information
1. 广州军区广州总医院检验科(广州 510010
- Keywords:
CXCR family proteins;
Breast cancer;
TCGA;
Prognosis
- From:
Practical Oncology Journal
2019;33(3):206-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aims of this study were to determine the expression of CXCR family proteins in various subtypes and adjacent tissues of breast cancer and its relationship with prognosis,and to provide a reference for clinical diagnosis,treatment and prognosis of breast cancer. Methods The mRNA expressive profiles of CXCR family proteins in paracancerous tissues and different subtypes of breast cancer tissues were obtained from the TCGA(The Cancer Genome Atlas)database. The prognostic survival analysis of each differentially expressed protein was obtained using the PRECOG website. Results Except for CXCR1,the expression of CX-CR family proteins in breast cancer tissues and adjacent tissues was statistically different( P<0. 05). CXCR2P1,CXCR3,CXCR4, CXCR5 and CXCR6 were highly expressed in breast cancer tissues,CXCR2 and CXCR7 were lowly expressed in breast cancer tis-sues. The expressive levels of CXCR3,CXCR4 and CXCR7 were associated with the prognosis of patients. Conclusion The expres-sions of CXCR3,CXCR4 and CXCR7 in breast cancer tissues and adjacent tissues is significantly different,and its expression is related to the prognosis of breast cancer patients,which may be a potential target for molecular diagnosis or targeted therapy of breast cancer.
