Toll-like receptor signaling pathway as a potential therapeutic target for colorectal cancer
10. 11904/j. issn. 1002-3070. 2019. 02. 017
- VernacularTitle:Toll样受体信号通路作为结直肠癌潜在治疗靶点的研究进展
- Author:
Hengchen LIU
1
;
Xinyu ZHANG
Author Information
1. 哈尔滨医科大学附属第二医院(哈尔滨 150001
- Keywords:
Colorectal cancer;
Immune response;
Toll-like receptor signaling pathway
- From:
Practical Oncology Journal
2019;33(2):188-192
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors(TLRs) signaling pathways are involved in the activation of innate and adaptive immune re-sponse and play an important role in the development of colorectal cancer. Deregulation of TLRs signaling pathway can lead to epitheli-al hemorrhage,chronic inflammation and the development of colorectal cancer. There is now lots of evidence that targeting this pathway will benefit the treatment of colorectal cancer,such as BCG,monophosphatidyl A,and iquimod,etc. ,which are now in clinical use. This article reviews current different function of TLRs in tumor development and their application in the treatment of colorectal cancer.
