Interrupted time series trial for prevention of cardiovascular toxicity induced by chemotherapy in cervical cancer
10. 11904/j. issn. 1002-3070. 2019. 02. 007
- VernacularTitle:宫颈癌化疗心血管毒性预防的间断时间序列试验
- Author:
Hong LIANG
1
;
Qi LI
;
Yaoxian WANG
;
Hong JIN
;
Tong WANG
;
Yanan WANG
;
Yani DUAN
;
Min SONG
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所(哈尔滨 150081)
- Keywords:
Interrupted time series trial;
Cervical cancer;
Cardiovascular toxicity;
Chemotherapy;
Translation
- From:
Practical Oncology Journal
2019;33(2):134-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to establish a practical and feasible prevention,and a treatment scheme of cardiovascular toxicity(CVT)induced by chemotherapy in cervical cancer based on known effective measures and to provide scientific guidance and basis for clinical treatment. Methods The risk of pre-chemotherapy CVT and post-chemotherapy CVT were evalua-ted in 164 subjects from November 2016 to January 2018. The Interrupted time series(ITS)model of CVT incidence before and after intervention was established. The CVT biomarkers and results of clinical examination before and after chemotherapy were compared in selected patieds. The effects of measures were evaluated. Results There was no difference in the ITS model of CVT incidence before and after intervention(P>0. 05). Among echocardiography examination results,the E peak velocity of mitral valve and E/A ratio in-creased,and the difference was statistically significant(P<0. 05),LVEF、FS、SV and A peak velocity of mitral valve had no differ-ences(P>0. 05). There were no differences in ECG and double lower extremities arteriovenous ultrasonography results(P>0. 05). The level of sICAM-1,sTM,vWF and h-FABP decreased(P<0. 05),the levels of NO and eNOS increased(P<0. 05);there was no significant difference in the levels of hs-CRP and E-selectin(P>0. 05). Conclusion The comprehensive prevention and treat-ment program established in this study can improve the cervical cancer chemotherapy CVT microscopically, and further research should be carried out by expanding the sample size.
