Research progress on potential targets of liposarcoma
10.11904/j.issn.1002-3070.2019.01.015
- VernacularTitle:脂肪肉瘤潜在作用靶点的研究进展
- Author:
Zhichao XING
1
;
Wei MAI
Author Information
1. 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081
- Keywords:
Liposarcoma;
Targets;
Treatment
- From:
Practical Oncology Journal
2019;33(1):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Liposarcoma(LPS)is the most common type of soft-tissue sarcoma(STS). The current treatment methods are still based on complete surgical resection. Radiotherapy and chemotherapy as adjuvant treatment or distant metastasis,and the main treat-ment of unresectable liposarcoma have limited efficacy,have not widely recognized. With the extensive and in-depth of LPS molecular targeted therapy,the research achievements in this area are remarkable. Emerging targets for LPS include receptors such as tyrosine ki-nase receptor AXL,fibroblast growth factor receptor(FGFR),insulin-like growth factor-1 receptor(IGF-1R),nuclear export re-ceptor XPO1(Exportin-1),and proteins/enzymes such as heat shock protein 90( Hsp90),bispecific tyrosine( Y) phosphorylation-regulated kinase 1B( DYRK1B) and signal pathways such as SRC/FAK/RHO/ROCK have shown good prospects for anti-LPS in preclinical studies. The research progress in the aspects is summarized as follows.
