Expression of COL5A2 in bladder cancer tissues and its correlation with clinicopathological features and prognosis
10.11904/j.issn.1002-3070.2019.01.009
- VernacularTitle:COL5 A2在膀胱癌组织中的表达及其与临床病理特征和预后的相关性分析
- Author:
Hongbo YANG
1
;
Jie SHI
;
Yong YE
;
Wencheng LI
;
Zhaoping DENG
Author Information
1. 湖北省洪湖市人民医院泌尿外科(洪湖 433200
- Keywords:
COL5A2;
Bladder cancer;
Clinicopathological features;
Prognosis
- From:
Practical Oncology Journal
2019;33(1):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the expression of COL5A2 in bladder cancer tissues,and its correlation with clinicopathological features and prognosis. Methods A total of 144 patients with bladder cancer were enrolled in this study. Real-time fluorescence reverse transcription and immunohistochemistry were used to detect the expression of COL5A2 at levels of mRNA and protein in bladder cancer tissues and normal bladder tissues. The relationship between COL5A2 expression and clinico-pathological features and prognosis was analyzed. Results The expression of COL5A2 mRNA in the bladder cancer group was higher than that in the paracancerous group(P<0. 05). The positive rate of COL5A2 in the bladder cancer group was higher than that in the normal bladder tissues(P<0. 05). The expression of COL5A2 protein was not correlated with age( P>0. 05),positively associated with the TMN stage,pathological grade,tumor maximum diameter(≥5 cm),depth of invasion,lymph node metastasis,lymphatic vas-cular infiltration,and recurrence;the difference was statistically significant(P<0. 05). The 3-year survival rate and survival time in the COL5A2 negative group were significantly higher than those in the COL5A2 positive group(P<0. 05). The higher TMN stage,the higher pathological stage,the maximum diameter of the tumor(≥5 cm),the deeper infiltration depth,lymph node metastasis,lymphat-ic vascular infiltration,recurrence,the higher positive expression rate of COL5A2 protein. Conclusion COL5A2 is highly expressed in the bladder cancer tissues, which promotes the development of bladder cancer. Bladder cancer patients with low expression of COL5A2 can obtain a good prognosis.
