Effectsofnucleusaccumbensablativesurgeryonamplitudeoflow-frequencyfluctuationsofbrain inheroindependentpatients:aresting-statefunctionalmagneticresonanceimagingstudy
10.3969/j.issn.1002-1671.2019.07.002
- VernacularTitle:伏隔核缺失对海洛因成瘾者大脑低频振幅影响的静息态功能磁共振成像研究
- Author:
Fan WANG
1
;
Xiaohuai LI
;
Feng HU
;
Jing CHEN
;
Wei LIU
;
Jiajie CHEN
;
Qiang LI
;
Longxiao WEI
;
Wei WANG
Author Information
1. 空军军医大学唐都医院1放射科
- Keywords:
heroindependent;
nucleusaccumbens;
amplitudeoflow-frequencyfluctuations;
magneticresonanceimaging
- From:
Journal of Practical Radiology
2019;35(7):1034-1037,1053
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toinvestigatethechangesinbrainfunctionofheroindependentindividualsafternucleusaccumbens(NAC) ablativesurgery.Methods Twenty-fourheroindependentindividualsafterNACablativesurgery(NACgroup),27heroindependent individualsinshort-termabstinence(HDgroup)and32healthycontrol(HCgroup)wereincludedaresting-statefMRIstudy.Amplitudeoflow-frequencyfluctuations(ALFF)valuesofeachparticipantswerecalculated.DiffernecesinALFFvalueamongthethreegroupswere analyzed by One-Way ANOVA .Results Brain regions with statistically significant A L F F differences a m ong the three groups included left cerebellum,rightposteriorcentralgyrus,leftcaudatenucleus,rightmiddlefrontalgyrus,leftcuneusandbilateralinferiortemporal gyrusI.ntherightcentralposteriorgyrus,theALFFvalueofHDgroupwaslowerthanthatofNACandHCgroupI.ntheleftcerebellum,the ALFFvalueofHDgroupwashigherthanthatofNACandHCgrouprespectivelyI.nbilateralinferiortemporalgyrusandleftcaudatenucleus, ALFFvaluesofNACandHDgroupswerelowerthanHCgroup.ALFFvaluesofNACandHDgroupswerehigherthanHCgroup inrightmedialfrontalgyrusandleftcuneus.Conclusion InheroindependentindividualsafterNACablativesurgery,theALFFvaluesofleft cerebellumandrightposteriorcentralgyrustendtobenormal.NodifferenceinALFFvalueinregionsofdefaultmodenetworkbetweenNACand HDgroups.
