The value of DCEGMRI in predicting response to neoadj uvant chemotherapy in tripleGnegative breast cancer
10.3969/j.issn.1002G1671.2019.06.014
- VernacularTitle:动态对比增强磁共振成像特征对三阴性乳腺癌新辅助化疗肿瘤反应的预测价值研究
- Author:
Dezhang LIU
1
;
Xiaozhong ZHOU
;
Xin HUANG
;
Zhi LI
;
Cuiyu LIU
;
Dihang LI
Author Information
1. 广西桂东人民医院影像科
- Keywords:
tripleGnegative breast cancer;
dynamic contrastGenhanced magnetic resonance imaging;
neoadjuvant chemotherapy;
pathologically complete response
- From:
Journal of Practical Radiology
2019;35(6):909-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of DCEGMRI findings with pathologic tumor response to neoadjuvant chemotherapy for patients with tripleGnegative breast cancer (TNBC).Methods SixtyGnine patients with TNBC were enrolled,who underwent DCEG MRI before neoadj uvant chemotherapy,then completed neoadjuvant chemotherapy and surgery.Patterns of tumor volume reduction were divided into two types.Univariate and multivariate Logistic regression analyses were performed to detect the independent predictors of pathological tumor response.Results 30.4% (21/69)patients achieved a pathologic complete response.Multivariate Logistic regression analysis showed that homogenous enhancement on preGneoadj uvant chemotherapy MRI (OR＝1 0.87 ,9 5%CI＝2.94－48.3 1 ,P＜0.00 1 )and concentric shrinkage pattern on postGneoadj uvant chemotherapy (OR＝1 3.04,9 5%CI＝2.0 1－54.1 1 ,P＜0.00 1 )were the independent predictors of pathologic complete response.Conclusion Homogeneous enhancement on preGneoadj uvant chemotherapy MRI and the presence of concentric shrinkage pattern are correlated with pathologically complete response in patients with TNBC.
