BrainactivityalterationsofParkinson’sdiseasepatientswithfreezingofgaitunderrestingGstatefunctionalMRI
10.3969/j.issn.1002-1671.2019.05.003
- VernacularTitle:帕金森病冻结步态局部脑活动改变的静息态功能磁共振成像研究
- Author:
Min WANG
1
;
Jianwei WANG
;
Kezhong ZHANG
;
Yongsheng YUAN
;
Kai ZHENG
;
Weiben WU
Author Information
1. 南京医科大学附属江苏盛泽医院放射科
- Keywords:
Parkinson’sdisease;
freezingofgait;
resting-statefunctionalmagneticresonanceimaging;
regionalhomogeneity
- From:
Journal of Practical Radiology
2019;35(5):693-698
- CountryChina
- Language:Chinese
-
Abstract:
Objective ToinvestigatethepatternsofbrainactivityabnormalitiesinpatientswithParkinson’sdisease(PD)with freezingofgait(FOG),andtoexploretheneuropathologicalmechanismofFOG.Methods Resting-statefunctionalMRI(rs-fMRI) scanswereobtainedfrom31PDpatientsand16healthycontrols(HCs).Accordingtothefreezingofgaitquestionnaire(FOG-Q),31 PDpatientsweredividedinto15PDFOG(+)and16PDFOG(－).ANCOVAandPost-Hocttestwereperformedtoassessinter groupdifferenceofbrainactivityabnormalitybasedonregionalhomogeneity.Results ComparedtoHCs,PDFOG(+)showeddecreased ReHointheleftinferiortemporalgyrus,rightlingual,bilateralfusiform,rightoccipitalgyrus,rightcalcarine,andrightcerebellum, whileincreasedReHointherightmiddlefrontalgyrus,rightsuperiorfrontalgyrus,rightprecentralgyrus,andrightsupplementary motorarea(SMA).ComparedtoPDFOG(－),PDFOG(+)exhibitedincreasedReHointherightprecentralgyrus,rightmiddle frontalgyrus,rightinferiorfrontalgyrus,andrightSMA,whiledecreasedReHoinleftfusiform.Conclusion Thisstudysuggests thatFOGinPDisassociatedwithabnormalitiesincerebellum,frontallobeandvisualnetwork,whichishelpfultounderstandthe neuralmechanismsunderlyingFOGinPD.
