TopredicttheKi-67expressioninbreastcancerbasedon MRappearences
10.3969/j.issn.1002-1671.2019.04.013
- VernacularTitle:乳腺癌MR影像表现预测Ki-67表达水平
- Author:
Yanping WANG
1
;
Hongchun ZHU
;
Jun MAO
;
Yutao LIU
;
Yunhui LUO
;
Min CHEN
;
Xiubin PENG
Author Information
1. 暨南大学附属珠海医院 珠海市人民医院放射科
- Keywords:
breastcancer;
diffusion-weightedimaging;
time-signalintensitycurve;
Ki-67
- From:
Journal of Practical Radiology
2019;35(4):565-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective ToinvestigatethefeasibilityofpredictingtheKi-67expressionusing MRandclinicalfeaturesofbreast cancer.Methods 52patientswith56invasivebreastcarcinomawereretrospectivelyinvestigated.Eachsubjectunderwentpresurgical breastMRI,whichincludeddynamiccontrastenhancementandDWI(b=0s/mm2,1000s/mm2).Clinicalcharacteristicsand MR findingswerecollected,includingage,ER ,PR ,HER2,tumorsize,location,number,spiculesign,lobulationsign,margin,TICandADCvalues. Ki-67expressionwasrecordedbyimmunohistochemicalstaining,whichwasdividedintohighexpression(≥20%)andlowexpression (<20%).Leastabsoluteshrinkageandselectionoperator(Lasso)wereperformedtoselectthefeaturesmostassociatedwithKi-67 expression.ThenomogramwasconstructedtopredictKi-67expression,aswellasAUCand95%confidenceinterval(CI)werecalculated.Results TICtypesandADCvaluesassociatedwithKi-67expressionwereidentifiedbyLassoregression.Thenomogram predictedthehigh andlow Ki-67expressionwithanAUCof0.827 (95% CI:0.713-0.940).TheKi-67expressionwasnegativelycorrelatedwiththe ADCvalues(r=-0.430,P=0.003).Ki-67expressionwassignificantlycorrelatedwithTICtype,andTICⅢwasmorelikelytohavehigher expressionofKi-67.Conclusion ThereisindividualandrespectivecorrelationbetweentheexpressionlevelofKi-67andTICtype, ADCvalue.TheexpressionlevelofKi-67canbepredictedtosomeextentbyADCvaluesandTICtypes.
