Abnormalspontaneousbrainactivityintype2diabeticsretinopathyrevealedby amplitudeoflow-frequencyfluctuations:Aresting-statefMRIstudy
10.3969/j.issn.1002-1671.2019.04.005
- VernacularTitle:基于低频振幅分析2型糖尿病视网膜病变患者静息态脑功能的MRI研究
- Author:
Zhongdan LI
1
;
Xiaomin GE
;
Hong ZHOU
;
Zhongling WANG
Author Information
1. 象山县红十字台胞医院放射科
- Keywords:
resting-statefunctionalmagneticresonanceimaging;
diabeticretinopathy;
amplitudeoflow-frequencyfluctuation
- From:
Journal of Practical Radiology
2019;35(4):531-534,540
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toinvestigatethealteredspontaneouscerebralactivitypatternsinpatientswithtype2diabeticretinopathy (DR).Methods 21patientswithDRand17healthycontrolsubjectswereprospectivelystudied.Allindividualsunderwentlaboratoryand neuropsychologicaltests.Thedifferencesintheamplitudeoflow-frequencyfluctuation (ALFF)valuesbetweentwogroupswere comparedandanalyzedstatisticallyusingDPRASFV2.3andREST1.6software.TherelationshipsamongALFFvaluesofbrainregionswith statisticalsignificance,HbA1c,durationofdiseaseandneuropsychologicalscoreswereanalyzedusinga multiple-factoranalysis.Results Comparedtothecontrols,theDRgroupshowedsignificantlyincreasedALFFvaluesinthebilateraloccipitalgyrus,rightlingualgyrus,and precuneus(P<0.01),anddecreasedvaluesintherightposterior/anteriorcerebellarlobe,fusiform,superiortemporal,inferiorparietal,and angulargyrus(P<0.05).Furthermore,theMoCAscoreswerenegativelycorrelatedwithdecreasedALFFvaluesintherightoccipitallobe oftheDRgroup,whileincreasedALFFvaluesintherightprecuneusandlingualgyruswerefoundtobepositivelycorrelatedwithglycosylated hemoglobin(HbA1c)levels.Conclusion PatientswithDRshowspontaneouscerebralabnormalactivityin manycerebralregions.ALFF valuechangesinthevisualcortexareassociatedwithcognitiveimpairments.Itisofimportantvaluetoevaluatebraindysfunctionin patientswithDRusingALFF method.
