The Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart Failure.
10.4070/kcj.1998.28.12.1964
- Author:
Hyung Wook PARK
;
Myung Ho JEONG
;
Sang Hyun LEE
;
Kyung Tae KANG
;
Joon Woo KIM
;
Sung Hee KIM
;
Jang Hyun CHO
;
Young Keun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Young Jun KANG
;
Jung Chaee KANG
- Publication Type:Original Article
- Keywords:
Ischemic left ventricular failure;
Cilazapril;
Ventricular remodeling
- MeSH:
Blood Pressure;
Chemistry;
Cilazapril*;
Cough;
Dilatation;
Dizziness;
Edema;
Electrocardiography;
Heart Failure*;
Heart Rate;
Heart*;
Humans;
Hypotension;
Myocardial Infarction;
Peptidyl-Dipeptidase A;
Ventricular Remodeling*
- From:Korean Circulation Journal
1998;28(12):1964-1972
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Angiotensin converting enzyme inhibitor (ACEI) is known to be effective in the prevention of left ventricular failure (LVF) after acute myocardial infarction. The aim of this study was to investigate the efficacy of an ACEI, Cilazapril, on left ventricular remodeling in patients with ischemic LVF, who underwent coronary interventions. MATERIALS AND METHODS: Cilazapril, 2.5 - 5.0 mg per day was administ-ered 12 weeks after coronary interventions in 25 patients (18 M, 7 F, 61.5+/-9 years) with impaired LV function (ejection fraction< or = 50%). Fifteen patients (9 M, 6 F, 59.4+/-7 years) without ACEI were compared by clinical examinations, blood chemistry, electrocardiogram and echocardiogram with Cilzapril group at 2, 4, 8 and 12 weeks after intervention. RESULTS: Blood pressure and heart rate were not changed after Cilazapril. LV end-diastolic volume (LVEDV) decreased from 153.1+/-38.7 to 135.6+/-25.5 ml and end-systolic volume from 84.9+/-34.7 to 72.6+/-25.1 ml after 12-week Cilazapril p=0.003, p=0.001. Ejection fraction (EF) was increased from 44.4+/-3.2 to 52.4+/-2.8% after 12 weeks of Cilazapril p=0.034. In control group, LVEDV was changed from 152.7+/-44.6 to 143.6+/-28.7 ml, which failed to show significant reduction. Side effects of Cilazapril were 3 dry cough (3/25, 12%) and 1 facial edema, 1 hypotension and 1 dizziness. CONCLUSION: Cilazapril is a beneficial adjunctive therapeutic agent in patients with ischemic left ventricular failure for the prevention of ventricular dilatation, especially after coronary intervention.
