Research progress in the eXpression of uridine diphosphate－glucuronosyl transferase 1A1 gene polymorphism
10. 3760∕cma. j. issn. 2095_428X. 2019. 05. 019
- VernacularTitle:尿苷二磷酸葡萄糖醛酸转移酶1A1基因多态性的表达研究进展
- Author:
Hong CHEN
1
;
Danni ZHONG
Author Information
1. 广西医科大学第一附属医院儿科
- Keywords:
Uridine diphosphate_glucuronosyl transferase 1A1 gene;
Dolymorphism;
Unconjugated hyperbi_lirubinemia;
Enzyme activity
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(5):388-391
- CountryChina
- Language:Chinese
-
Abstract:
The uridine diphosphate_glucuronosyl transferase 1A1(UGT1A1)gene mutation can affect the ex_pression of UGT1A1 gene and enzyme activity,and then reduce bilirubin metabolism leading to unconjugated hyperbi_lirubinemia. With the development of molecular biotechnology,more and more studies are trying to identify the patho_genesis of these polymorphisms by analyzing the expression and enzyme activity of UGT1A1 gene polymorphisms. Now, the progresses in the study of the expression of UGT1A1 gene polymorphism were reviewed.
