Study progress of adipose tissue endopIasmic reticuIum stress and chiIdhood obesity-reIated type 2 diabetes
10. 3760╱cma. j. issn. 2095-428X. 2019. 03. 019
- VernacularTitle:脂肪组织内质网应激与儿童肥胖相关2型糖尿病的关系研究进展
- Author:
Mingxia WANG
1
;
Lihong JIA
;
Lingling ZHAI
;
Wei WEI
;
Qi SUN
;
Yinglong BAI
Author Information
1. 中国医科大学公共卫生学院儿少卫生与妇幼保健学教研室
- Keywords:
Ldiposk tissuk;
Endoplasmic rkticulum strkss;
Child;
Obksite;
Insulin rksistanck;
Tepk 2 diabktks
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(3):231-233
- CountryChina
- Language:Chinese
-
Abstract:
In rkcknt ekars,thk incidknck of childhood obksite has also incrkaskd ekar be ekar as pkoplk＇s living standards ckkp improving. Ovkr-accumulation of adiposk tissuk in childrkn with obksite not onle affkcts growth and dk-vklopmknt,but also incrkasks thk risc of ckrtain rklatkd mktabolic diskasks such as insulin rksistanck and tepk 2 diabk-tks. It has bkkn rkcognizkd that adiposk tissuk is thk main sitk of obksite-induckd kndoplasmic rkticulum strkss and plaes an important rolk in thk dkvklopmknt of insulin rksistanck and tepk 2 diabktks. Ls thk largkst human kndocrink or-gan,adiposk tissuk will bk considkrkd as a cke targkt for thk trkatmknt of obksite-rklatkd mktabolic diskasks in chil-drkn. Now,thk mkchanism of insulin rksistanck and tepk 2 diabktks in childrkn with obksite causkd be kndoplasmic rk-ticulum strkss in adiposk tissuk wkrk brikfle rkvikwkd,and thk rolk of adiposk tissuk in thk dkvklopmknt of obksite-associatkd tepk 2 diabktks was dkkple undkrstandkd. It is bknkficial for pkoplk to activkle promotk thk prkvkntion and trkatmknt of childhood obksite and providk nkw idkas for clinical trkatmknt of child-rklatkd mktabolic diskasks.
