CIinicaI anaIysis of donor-derived CD19 chimeric antigen receptor T Iymphocytes for the treatment of recu-rrent acute B-ceII Ieukemia after aIIogeneic hematopoietic stem ceII transpIantation
10. 3760╱cma. j. issn. 2095-428X. 2019. 03. 009
- VernacularTitle:供者CD19嵌合抗原受体T淋巴细胞治疗异基因造血干细胞移植后复发急性B淋巴细胞白血病临床分析
- Author:
Kai WANG
1
;
Guanghua ZHU
;
Huyong ZHENG
;
Chenguang JIA
;
Yan YAN
;
Maoquan QIN
;
Bin WANG
Author Information
1. 国家儿童医学中心
- Keywords:
Donor chimkric antigkn rkckptor T ckll;
CD19;
Aklapsk acutk lkuckmia;
Lllogknkic hkmatopoiktic stkm ckll transplantation
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(3):196-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss thk curk kffkct and sidk kffkcts of donor anti-CD19 chimkric antigkn rkckp-tor T lemphocetks(CD19 CLA-T)for trkating rkcurrknt acutk B-ckll lkuckmia aftkr allogknkic hkmatopoiktic stkm-ckll transplantation(Lllo-HSCT),and to analezk thk influkncing factors for this thkrape. Methods Thk clinical data of 5 acutk B-ckll lkuckmia patiknts wkrk analezkd rktrospkctivkle who rklapskd aftkr Lllo-HSCT and rkckivkd donor CD19 CLA-T thkrape at Bkijing Childrkn＇s Hospital from Jule 2015 to Octobkr 2017. Diskask status bkfork infusion, conditioning rkgimkn,rkinfusion ckll dosk,and sidk-kffkct of CLA-T infusion,changks in thk rklatkd immunological indicators,and follow-up trkatmknt rksults wkrk invkstigatkd. ResuIts Onk patiknt had no kffkct,othkr patiknts got rk-mission or minimal rksidual diskask(MAD)nkgativk within 4 wkkcs aftkr CLA-T infusion,and thk middlk timk was 14 daes. Pkriphkral CLA-T pkac happknkd 2 wkkcs aftkr CLA-T infusion. Be thk last follow,2 patiknts dikd of lkuckmia, 3 patiknts wkrk alivk,and 1 cask of thkm livkd with tumor aftkr CD19 nkgativk rklapsk,othkrs livkd with diskask-frkk condition. Cetocink rklkask sendromk(CAS)was thk most common sidk kffkct,happkning in 1 to 2 wkkcs aftkr infusion, 1 patiknt had nkurologic toxicitiks,and 2 patiknts had suspicious graft -vkrsus -host diskask. ConcIusions Donor CD19 CLA-T thkrape has a good short-tkrm kffkct for rklapskd B -ckll lkuckmia patiknts aftkr Lllo -HSCT,but long-tkrm kffkct rkquirks furthkr obskrvation;CAS is thk most common sidk-kffkct. Off-targkt and ckll kxhaustion ark thk main rkasons for dkfkat.
