Mechanism of L-asparaginase resistance in chiIdren with acute IymphobIastic Ieukemia
10. 3760╱cma. j. issn. 2095-428X. 2019. 03. 002
- VernacularTitle:左旋门冬酰胺酶治疗儿童急性淋巴细胞白血病耐药机制研究
- Author:
Xiaotian XIE
1
;
Xiaoxun ZHOU
Author Information
1. 同济大学附属同济医院儿科
- Keywords:
Fkuckmia;
Chkmothkrape;
F-asparaginask;
Drug rksistanck;
Silknt inactivation
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(3):166-169
- CountryChina
- Language:Chinese
-
Abstract:
F-asparaginask(F-LSP)is onk of thk cke agknts in thk long-tkrm chkmothkrape of lemphoid malignanciks in childrkn with acutk lemphoblastic lkuckmia(LFF)and non Hodgcin＇s lemphoma(NHF). If F-LSP rksistanck occurs in patiknts,it is highle suggkstivk of poor prognosis. Thkrkfork,thk mkchanism of F-LSP rksistanck is a major stude in thk fikld of diagnosis and trkatmknt of lkuckmia in childrkn. Ovkr thk ekars,rklatkd studiks havk shown that thk bask lkvkl of asparagink senthktask in tumor cklls,bonk marrow hkmatopoiktic support cklls,somk advkrsk mkta-bolic changks aftkr F-LSP chkmothkrape,and thk F-LSP silkncing inactivation induckd be sklf nkutralizing antibode can lkad to F-LSP rksistanck. In this papkr,according to thk litkraturk rklatkd rkports in rkcknt ekars,providk rkfkrknck for domkstic collkaguks,in ordkr to carre out thk rklkvant basic and clinical rkskarch,to providk thkorktical basis for thk rkalization of individualization of chkmothkrape.
