Screening of Traditional Chinese Medicine that Enhance the Sensitivity of Methicillin-resistant Staphylococcus aureus to Antibiotic
- VernacularTitle:增强耐甲氧西林金黄色葡萄球菌抗生素敏感性的中药筛选
- Author:
Ru LU
1
;
Guiyu LU
;
Zhezhe LIN
;
Hongjie ZHENG
;
Dongqing CHENG
Author Information
- Keywords: Methicillin-resistant Staphylococcus aures (MRSA); synergy; enhanced inhibition; screening of medicine
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(12):2217-2223
- CountryChina
- Language:Chinese
- Abstract: Objective: To study the changes of the sensitivity of the methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin after Chinese herbs. effects, so as to find Chinese medicine that can enhance the sensitivity of MRSA to antibiotics and provide new ideas for the clinical treatment of MRSA infection. Methods: A total of 33 commonly used antibacterial herbs were selected to prepare extracts, which act on clinically isolated MRSA. The broth micro dilution method was used to determine the minimal inhibitory concentration (MIC) of oxacillin on MRSA before and after the action of Chinese medicine. If there is a statistically significant difference (P ＜ 0.05), the medicine is effective. Results:The MIC of oxacillin on MRSA were 128-512 μg·ml-1, after the effect of Bletilla extracts, the change of MIC showed a statistically significant difference (P ＜ 0.05), which could increase the sensitivity of MRSA (271) to oxacillin. Conclusion:Bletilla extracts can enhance the sensitivity of MRSA (271) to oxacillin and the compatibility with antibiotics is expected to restore the efficacy of antibiotic.
