A Network Pharmacology Approach to Explore the Molecular Mechanism of Taoren-Honghua Pair on Syndrome of Blood Stasis
10.11842/wst.2018.12.019
- VernacularTitle:基于网络药理学探讨桃仁-红花药对活血化瘀的分子机制
- Author:
Kailin YANG
1
;
Liuting ZENG
;
Anqi GE
;
Jinwen GE
;
Zhiyong LONG
;
Tingting BAO
;
Yan JIANG
Author Information
1. 湖南中医药大学医学院 长沙 410208
- Keywords:
Taoren-honghua pair;
syndrome of blood stasis;
promoting blood circulation for removing blood stasis;
Chinese medicine;
network pharmacology
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2018;20(12):2208-2216
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the molecular mechanism of Taoren-Honghua herb pair (THP) on syndrome of bloodstasis based on the network pharmacology. Methods: We collected THP's compounds from traditional Chinese Medicinedatabases and input them into Pharm Mapper to get their potential targets, and collected the known targets of compoundsby Scifinder. Then we did KEGG-pathway analysis by DAVID database. Finally draw and analyze the network byCytoscape by information above. Results: Seventeen compounds of THP acquired 74 known targets, which was associatedwith four modules: improving the hemodynamics, anticoagulation, anti-inflammation, regulating apoptosis andproliferation. We also got 317 potential targets through PharmMapper and got 128 signaling pathway through pathwayenrichment including 39 disease-related pathways, 25 endocrine-related pathways, 11 immune-related pathways and soon. Conclusion: The four modules of the known target are exactly related to the four characteristics of the syndrome ofblood stasis. The potential targets and the 128 signal pathways involve a variety of pathophysiological processes of thesyndrome of blood stasis. These reflect the molecular mechanism of THP intervention in the syndrome of blood stasis
