Advances in Energy Metabolism and Alzheimer's Disease
- VernacularTitle:能量代谢与阿尔茨海默病研究进展
- Author:
Wen WEN
1
,
2
;
Lijuan GAO
;
Jiangping WEI
;
Lixia QIN
;
Yueqiang WEN
;
Shijun XU
Author Information
- Keywords: Alzheimer's disease; risky diseases; energy metabolism; mitochondria
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(12):2145-2149
- CountryChina
- Language:Chinese
- Abstract: Alzheimer's disease (AD) is a complex neurodegenerative disease. Its pathogenesis involves many factors such as environment, heredity, aging, diet, personal preference and underlying diseases. And the complex pathogenic factors of AD lead to many social and economic problems such as delayed diagnosis, difficulty of drug research and development, low cure rate and high cost of care. In this paper, the relationship between AD disease progression and its risky diseases such as metabolic diseases, chronic inflammatory diseases and cardiovascular diseases was analyzed based on energy metabolism abnormalities. The role of energy metabolism signal/path abnormality activity in the course of risk disease to AD disease was analyzed. Finally, it is suggested that the prevention and treatment of risk disease evolution and adjustment of abnormal energy metabolism signals may be effective strategies for the treatment of AD.
