Systematic Review of Danhong Injection on Endothelial Function after Percutaneous Coronary Intervention in Patients with Coronary Heart Disease
- VernacularTitle:丹红注射液对冠心病经皮冠状动脉介入术后内皮功能影响的系统评价
- Author:
Tianmai HE
1
;
Xinyu YANG
;
Ruijin QIU
;
Songjie HAN
;
Ya HUANG
;
Hongcai SHANG
Author Information
- Keywords: Danhong injection; coronary heart disease; percutaneous coronary intervention; endothelial function; systematic review
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(12):2126-2133
- CountryChina
- Language:Chinese
- Abstract: Objective: To evaluate the effect of Danhong injection on endothelial function after percutaneous coronaryintervention (PCI) in coronary heart disease (CHD) . It provides the basis for further research and design. Methods: Sevendatabases of CNKI, VIP, Wanfang Data, CBM, PubMed, The Cochrane Library, Embase and others were searched bycomputer cents with coronary heart disease treated by Danhong injection combined with conventional drugs. Twoevaluators independently sifted the literature, extracted the data and evaluated the bias risk in the study. The data werestatistically analyzed by RevMan 5.3 software. Results: A total of 12 RCTs, involving 1325 patients were included. Metaanalysis showed that the treatment group (Danhong injection combined with routine therapy) was superior to the controlgroup in improving the endothelium index after operation. The index NO[MD=9.57, 95％CI (8.22, 10.93), P ＜ 0.00001], vWF [MD=-31.60, 95％CI (-41.47, -21.72), P ＜ 0.00001], ET-1 [MD=-2.19, 95％CI (-3.11, -1.27), P ＜ 0.00001], ET[SMD=-0.92, 95％CI (-1.49, -0.35), P ＜ 0.01], FMD[MD = 1.81, 95％CI (1.26, 2.37), P ＜ 0.00001]. There was statisticalsignificance between each index. Conclusion: Danhong injection combined with conventional therapy can improveendothelial function after PCI. However, due to the low quality of included studies and the problem of heterogeneity, these conclusions need to be further verified by high quality multicenter, large sample and double blind randomizedcontrolled trials.
