Evidence-Based Optimization Research on the Timing of Traditional Chinese Medicine Intervention for Coronary Heart Disease: Trial Design and Thinking
- VernacularTitle:冠心病中医药干预时机的循证研究设计与思考
- Author:
Xiaoyu ZHANG
1
;
Yin JIANG
;
Yang SUN
;
Yan LIU
;
Lijing ZHANG
;
Hongcai SHANG
Author Information
- Keywords: Traditional Chinese medicine; coronary artery disease; timing of intervention; clinical research; evidence-based medicine
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(12):2114-2118
- CountryChina
- Language:Chinese
- Abstract: Traditional Chinese medicine (TCM) emphasizes treatment timing, and it believes that the timing of treatment is closely related to the curative effect. In the era of the Chinese and Western medicine combined application, it attaches new connotations on how to choose the timing of interventions. Defining the timing of intervention is one of the key links to make the best effect of Chinese medicine, and it is also the focus of clinical decision-making, which deserves research attention. This article expounded the significance of TCM intervention timing research, and pointed out that the alternative timing should be based on the baseline investigation and mechanism clues. This article also demonstrated some key points of intervention timing trial design, like the outcome indicators setting, sample size estimation, blinding and data analysis. With the examples of national key research and development program"evidence-based optimization and mechanism research of traditional Chinese medicine therapies for coronary artery disease (angina pectoris-myocardial infarction-heart failure) ", the timing of TCM intervention in myocardial infarction perioperative period and coronary heart disease related research cases aboard, we hope to provide reference for the intervention timing optimization research.
