Systematic Evaluation of Traditional Chinese Medicine Combined with Zoledronic Acid Treatment for Lung Cancer with Bone Metastasis
- VernacularTitle:中药联合唑来膦酸治疗肺癌骨转移的系统评价
- Author:
Xue KONG
1
,
2
;
Yingjie JIA
;
Honggen LIU
Author Information
- Keywords: Lung cancer; bone metastasis; traditional Chinese medicine; zoledronic acid; system evaluation
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(11):1936-1942
- CountryChina
- Language:Chinese
- Abstract: Objective: To prove the effect and decrease toxicity in the treatment of lung cancer with bone metastasis of Traditional Chinese medicine and provide service for clinical by comparing the efficacy of traditional Chinese medicine combined with zoledronic acid with pure zoledronic acid in the treatment of lung cancer with bone metastasis. Methods: A retrieval was made for randomized controlled trials of traditional Chinese medicine combined with zoledronic acid in the treatment of lung cancer with bone metastasis which have been included in CNKI, VIP, Wanfang, PubMed, EMbase and CMB to March, 2018, and meta-analysis was performed according to Cochran systematic evaluation method and Revman 5.0. Results: A total of 14 RCTs and 847 patients were included. Compared with control group, ache in the Traditional Chinese medicine combined with zoledronic acid group remarkably decreased (RR =1.50, 95％CI =1.35-1.68, P ＜ 0.000 01), while the living quality remarkably increased (RR =1.47, 95％CI =1.27-1.70, P ＜ 0.000 01), and there were significant role and advantages in improving TCM syndromes of patients (RR =5.69, 95％CI =2.26-14.34, P =0.000 2), prolonging TTP (MD =1.16, 95％CI =0.74-1.58, P ＜ 0.000 01), decreasing serum calcium (MD =-0.32, 95％CI =-0.46——0.17, P ＜ 0.000 1) and reducing adverse reactions (RR =0.51, 95％CI =0.32-0.81, P =0.005). Conclusion: Traditional Chinese medicine combined with zoledronic acid has remarkable curative efficacy and safety in the treatment of lung cancer with bone metastasis, and it may be widely used in clinical practice.
