Effects of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra on Level of Nogo-A/NgR/RhoA/ROCK mRNA in Acute Cerebral Infarction Rats
10.11842/wst.2018.10.017
- VernacularTitle:川芎赤芍对急性脑梗死大鼠Nogo-A/NgR/RhoA/ROCK mRNA水平的影响
- Author:
He HUANG
1
;
Yu GAN
;
Yuan YUAN
;
Min QIAO
;
Jin MA
Author Information
1. 辽宁省中医药研究院 沈阳 110034
- Keywords:
Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra;
acute cerebral infarction;
Nogo-A;
NgR;
RhoA;
ROCK
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2018;20(10):1816-1821
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate effects of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra on the relative expression of Nogo-A/NgR/RhoA/ ROCK mRNA in acute cerebral infarction rats. Methods: Healthy male SD rats were randomly divided into sham operation group, blank group, low dose, medium dose and high dose Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra group, Ginkgo biloba group, Nimodipine group, and each group was divided into 3 days, 7 days, 14 days three time points. Real-Time quantitative polymerase chain reaction (PCR) was used to detect Nogo-A/NgR/RhoA/ROCK mRNA relative expression changes of acute cerebral infarction rats. Results: Compared with the blank group and the sham operation group, the relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA was increased in the model group both at 3 days, 7 days and 14 days (P ＜ 0.05). After the treatment of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra, other than there was no significant difference between the low-dose group and the model group except for 7 days, the relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA in Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra groups was lower than that in the model group (P ＜ 0. 05). Conclusion: The relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA in acute cerebral infarction rats can be reduced by Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra.
