Using Prescription Sequence Symmetry Analysis to Analyze Adverse Drug Reactions of Traditional Chinese Medicine Injection
- VernacularTitle:处方序列对称分析在研究中药注射剂不良反应中的应用展望
- Author:
Jing HU
1
;
Shuo FENG
;
Bo LI
;
Huina ZHANG
;
Hongcai SHANG
Author Information
- Keywords: Prescription sequence symmetry analysis; traditional Chinese medicine injection; adverse drug reaction; real world; signal detection
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(10):1739-1744
- CountryChina
- Language:Chinese
- Abstract: Traditional Chinese medicine (TCM) injections are very useful in the treatment of acute and severe diseases due to their rapid onset. While, adverse drug reactions (ADRs) of TCM injections is an important problem, how to quickly detect ADRs signal of TCM injections is a key and difficult issue to make sure the safely application of TCM injections.Prescription sequence symmetry analysis (PSSA) is an effective surveillance tool for drug associated ADRs, through examining the distribution of marker drugs (potentially used for managing ADRs), before and after initiation of index drugs, PSSA can evaluate the causal association of index drugs and ADRs. PSSA can quickly detect ADRs signal based on medical electronic databases or prescription databases, which is suitable for the rapid emergence of ADRs for TCM injections. We described the basic principle and worldwide researches of PSSA, then we introduced the research methods when using PSSA to analyze the three aspects of ADRs for TCM injections. At present, when we use PSSA to detect ADRs signals in electronic prescription databases in China, we still need to think about the number of patients, structure and combination of data. With the development of medical electronic databases in China, PSSA can be more used to detect ADRs signal.
