The Safety Evaluation Method of Herb-Drug Combination: Manifestation-Target Alliance
- VernacularTitle:中西药物联用安全性评价——"征靶关联法"的探索建立
- Author:
Rui ZHENG
1
;
Shiqi CHEN
;
Hongcai SHANG
Author Information
- Keywords: Herb-drug combination; safety evaluation methods; network-target analysis; clinical manifestation; mechanism characteristics
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(10):1734-1738
- CountryChina
- Language:Chinese
- Abstract: The herb-drug combination is becoming more and more common. The safety evaluation method is a complex evaluation system. This paper analyzed Pubmed database from 2008 to 2018, and summarized the characteristics of safety evaluation method, and the characteristics are listed as below: (1) Exposure safety issues in real world; (2) The combination use is complex and difficult to evaluate. There are the existing safety assessment methods including literature induction, prospective test, questionnaire survey, etc. Although safety evaluation has been carried out from different angles, there is still a lack of comprehensive and reasonable safety evaluation method. The team tried to combine clinical phenotype and mechanism characteristics to provide more reasonable methodological support for clinical safety evaluation.
