A Method Based on the Complex Network for Mining the System Biological Information of Scutellaria Barbata D. Don
- VernacularTitle:基于复杂网络的中药半枝莲系统生物学信息挖掘方法
- Author:
Chenjun HU
1
;
Ju HE
;
Jiadong XIE
;
Peipei FANG
;
Youwei DING
;
Kongfa HU
;
Yuqing MAO
Author Information
- Keywords: Complex network; Scutellaria barbata D. Don; system biological; genomics; KEGG signal pathway
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(9):1506-1514
- CountryChina
- Language:Chinese
- Abstract: Scutellaria barbata D. Don is widely used in TCM clinical practice, so it is important to delve the information of its system biology. In this paper, we integrate its natural compounds and genomics information. The Herb-Prince complex networks algorithm is used to delve potential associated genes, gene families and KEGG signal pathways for Scutellaria barbata D. Don, and the information is verified by literature. The top 100 genes, 4 gene families and 10 KEGG signaling pathways were found. The related results are highly consistent with the clinical and pharmacological studies of Scutellaria barbata D. Don, which provide decision support for researchers to study pharmacological activities of Scutellaria barbata D. Don at the molecular level.
