Mechanism Study on Active Ingredients of Danggui Shaoyao San for Treating Alzheimer's Disease Based on Biological Network
- VernacularTitle:当归芍药散活性成分治疗阿尔兹海默病作用机制的生物网络分析
- Author:
Zhenyan SONG
1
;
Yixuan CHEN
;
Jingping YU
;
Shaowu CHENG
Author Information
- Keywords: Network pharmacology; Danggui Shaoyao San; Alzheimer's disease; system analysis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(6):834-846
- CountryChina
- Language:Chinese
- Abstract: Objective: To study the mechanism of action of Danggui Shaoyao San (DSS) in the treatment of Alzheimer'sdisease (AD) from a systematic network level using network pharmacology. Methods: The active ingredients of DSS intreating AD was screened from the Traditional Chinese Medicine System Pharmacology Database (TCSMP), and thedrugs-targets-disease network was built. Target organ localization network, GO analysis and Pathway enrichmentanalysis were used for bioinformatics analysis. Results: 51 kinds of DSS active ingredients were screened by networkpharmacology, showing 377 predicted targets of active compounds. Among them, 197 targets were associated with AD, and the pharmacodynamic targets of DSS active compounds were highly enriched with AD-related signals. The pathwaywas closely related to the reduction of Aβ aggregation and inhibition of tau hyperphosphorylation and biological processessuch as anti-inflammatory and anti-apoptosis, and the mRNA expression of the targeted gene was mainly enriched in theliver, heart, and brain. Conclusion: DSS active compounds interact with multiple targets in multiple ways in a synergisticmanner, mainly to produce important therapeutic effects on AD with anti-inflammatory, anti-apoptotic, enhancingmetabolism and immune system.
