Studies on Medication Laws towards Rheumatoid Arthritis Based on Analysis and Comparison of Medicine Literatures
- VernacularTitle:基于文献多元分析的类风湿关节炎用药规律研究
- Author:
Chongxiang XUE
1
;
Hang YU
;
Mingzhe HU
;
Shenggang ZHANG
;
Shiyao SU
;
Lin ZHANG
Author Information
- Keywords: Rheumatoid arthritis; traditional Chinese medicine; modern literature; statistical analysis; medication law
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(4):608-613
- CountryChina
- Language:Chinese
- Abstract: This paper was aimed to study medication laws of traditional Chinese medicine (TCM) towards rheumatoid arthritis (RA) based on modern medicine literatures. The China National Knowledge Infrastructure (CNKI), Wanfang Data knowledge service platform and VIP Database for Chinese Technical Periodicals were searched from January 2000 to December 2016 for relevant literatures on TCM for treatment of RA. The results showed that the database was established and the data were analyzed with statistics method including frequency analysis and cluster analysis. Finally, a total of 292 articles, 214 kinds of herbs were included, with a total frequency of 5071 for herbs. The results of frequency analysis, showed that tonic drugs, medicine for eliminating wind and dampness, drug for invigorating blood circulation and eliminating stasis were the main medications, followed by heat-cleaning drug, relieving external syndrome drug, and dampness-draining drug. The most common tastes of high frequency were sweet, pungent and bitter. The most common natures were warm and mild. The related meridians included the liver meridian, spleen meridian and kidney meridian. It was concluded that the cluster analysis showed medicines in the core group were as following: Astragalus, Licorice, Chinese angelica, Monkshood, Cassia twig, Coix seed, Radix saposhnikoviae, Radix gentianae macrophyllae, Notopterygium, Caulis spatholobi, Rhizoma ligustici wallichii, Twotooth achyranthes root, and Radix clematidis. The common combinations of RA drugs were summarized by association analysis. The medication law of RA treatment is to enrich consumptive disease and support healthy energy, to tonify the liver and kidney, to dispel wind and eliminate dampness, to remove blood stasis and dredge collaterals.
