Study on Material Basis and Mechanism of ZiBu PiYin Recipe Prevent Mild Cognitive Impairment Based on Integrative Pharmacology of Traditional Chinese Medicine
- VernacularTitle:基于整合药理学平台探究滋补脾阴方药防治轻度认知功能障碍的物质基础与作用机制
- Author:
Wen ZHOU
1
;
Libin ZHAN
Author Information
- Keywords: Integrated pharmacology; Zibu piyin recipe; mild cognitive impairment; material basis; functional mechanism
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(4):488-495
- CountryChina
- Language:Chinese
- Abstract: To investigate the material foundation and mechanism of Zi Bu Pi Yin Recipe in the prevention and treatment of mild cognitive impairment. The integrated pharmacology platform was used to study the active ingredients, drug targets, and disease targets of 12 Chinese traditional medicines of Zi Bu Pi Yin Recipe, and to construct the target of"Zi Bu Pi Yin Recipe-Chinese herbal medicine-chemical composition-core Target-the key path "of the visual network and network analysis. Results:The platform screened 687 kinds of active ingredients of Zi Bu Pi Yin Recipe including glycosides, sugars and alcohols. and 595 key targets for treating mild cognitive impairment, Including HADHA, HADH, NAD (P) -dependent steroid dehydrogenase-like (NSDHL), and et al. The enrichment analysis of GO and KEGG showed that these key targets were mainly localized in the cytoplasm and mitochondria. The most common molecular functions were ATP binding and protein binding, and participated in purine metabolism, nucleotide metabolism, carbon metabolism pathway, Carbohydrate metabolism and so on. The platform could predict the key target of Zi Bu Pi Yin Recipe in preventing and treating Mild Cognitive Impairment and its related pathways, which lay a good foundation for further revealing its mechanism.
